D-serine serum levels in patients with schizophrenia: Relation to psychopathology and comparison to healthy subjects

Abstrakt

The main objective was to test the hypothesis of the association between D-serine serum levels and negative symptoms in patients with schizophrenia. Secondary objective was to examine the assumption of D-serine serum levels difference between a population of mostly chronic patients with schizophrenia and healthy controls.

We did not find any differences between patients (n=50) and controls (n=50) in D-serine serum levels. Patients had significantly lower total serine serum levels and higher D-serine/total serine ratio.

D-serine serum levels were not associated with the PANSS or the SANS total and subscales scores. Total serine serum levels inversely correlated with the SANS total and the PANSS negative symptom subscale scores.