Abstract
This review brings basic information on claudin 16 (CLDN 16) and claudin 19 (CLDN 19) and about clinical manifestation of their mutations. CLDN 16 and CLDN 19 regulate the paracellular transport of calcium and magnesium in the loop of Henle.
CLDN 16 and CLDN 19 are defective in autosomal recessive familial hypomagnesemia with hypercalciuria and nephrocalcinosis, resulting in renal insufficiency.