Publication at Faculty of Medicine in Hradec Králové |
2007
Abstract
Beta-hydroxy-beta-methylbutyrate (HMB) is the leucine metabolite, which shows anticatabolic effect and beneficially affects the immune system. The mechanism of action is still not fully understood.
HMB may serve as the source for cholesterol synthesis and it probably affects the ubiquitin-proteasome proteolytic system. HMB is used as a dietary supplement during resistance-training, especially for increase of power and non-fat body mass.
It has been also tested in recent years as a part of cachexia treatment (cancer, AIDS, etc.).