Publication at Faculty of Medicine in Hradec Králové |
2007
Abstract
The overview is devoted to our understanding of aminoglycoside antibiotics nephrotoxicity mainly focused on gentamicin. Toxicokinetics and dynamics on both subcellular (molecular) and clinical levels together with biomarkers indicating damage to target structures (molecules) are described including strategies of nephrotoxicity prediction and prevention.
The new perspective approach in seeking biomarkers specific to particular classes of target molecular damage, rapidly responsive, and predictive for the individual risks is mentioned.