Therapeutic Drug Monitoring (TDM) of Gentamicin in Critically ill Neonates

Abstrakt

First dose plasma concentrations of GE in neonates during the first week of postnatal age seem to be predictive for steady state concentrations in neonates without co-variates significantly modifying pharmacokinetics of GE. However, the results of Bland-Altman analysis indicate a lack of agreement between predicted and monitored GE concentrations in neonates administered furosemide, and/or suffering from systemic capillary leak syndrome.

The unexplained variability between observed and predicted values may originate from an effect of co-administered drugs and/or more serious clinical status of neonates. The variability requires further analysis.