Publication at Central Library of Charles University, Faculty of Medicine in Hradec Králové |
2007
Abstract
First dose plasma concentrations of GE in neonates during the first week of postnatal age seem to be predictive for steady state concentrations in neonates without co-variates significantly modifying pharmacokinetics of GE. However, the results of Bland-Altman analysis indicate a lack of agreement between predicted and monitored GE concentrations in neonates administered furosemide, and/or suffering from systemic capillary leak syndrome.
The unexplained variability between observed and predicted values may originate from an effect of co-administered drugs and/or more serious clinical status of neonates. The variability requires further analysis.