Pharmacodynamic of statins - development of the method for their determination in biological material

Abstrakt

A new UPLC-MS/MS method for the determination of atorvastatin and simvastatin as most widely used drug in the treatment of FH was described. The method is available, fast and precise.

It is convenient, after some modifications, for the determination of other statins, for pharmacodynamic studies and dosage adjustements in order to reach the best treatment effect as well.