Influence of methotrexate and L-carnitine on transintestinal transport of model substances (the rat small intestine in situ perfusion)

Abstract

Two substances were selected for the study of the transport processes and their influence in the small intestine in rat. Methotrexate (MTX) significantly increased the transport of indapamide on the way of passive diffusion, but the transport of 7-methoxytacrine (MEOTA) was not significantly affected by MTX.

L-Karnitine increased the absorption of MEOTA and galantamine after its previous in vivo premedication