Simultaneous infusion of glutamine and branched-chain amino acids (BCAA) to septic rats does not have more favorable effect on protein synthesis in muscle, liver and small intestine than separate infusions

Abstract

In septic rats we observed a decrease in glutamine concentration in blood and muscle, a decrease in BCAA in liver and jejunum and a decrease in protein synthesis in all tissues. Glutamine or glutamine+BCAA infusion increased glutamine concentration in plasma and muscle and stimulated protein synthesis in the liver.

The BCAA infusion enhanced concentrations of BCAA in blood and tissues, the effect on protein synthesis was insignificant. Synergistic effect of glutamine and BCAA on protein synthesis was not observed.