Effect of galanthamine on acetylcholinesterase and butyrylcholinsterase activities in the presence of L-carnitine in rat selected brain and peripheral tissues

Abstract

We attempted to achieve pharmacologically-induced enhancement of the parasympathomimetic activity of galanthamine in the key areas of rat brain, using an interactive combination of the alkaloid with the transmembrane enhancer L-carnitine. Carnitine in terms of positive modulation of galanthamine targeting to the central nervous system had no significant effect.