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Metabolic changes in the liver and thymus of rats with chronic liver failure

Publication at Central Library of Charles University, Faculty of Medicine in Hradec Králové |
2005

Abstract

We compared substrate utilisation in liver fibrosis or cirrhosis using microdialysis to follow interstitial concentration changes of urea, glucose, lactate and glycerol in peritoneal cavity, liver and thymus. Lower availability of glucose and lactate production in thymus in rats with chronic liver failure, thymocytes are not able to proliferate.

Fluctuation or decrease of interstitial concentrations of these metabolities could be explanation of pathophysiological changes in distant organs.