Aberrant nuclear/cytoplasmic localization and gene mutation of beta-catenin in classic pulmonary blastoma - beta-catenin immunostaining is useful for distinguishing between classic pulmonary blastoma and a blastomatoid variant of carcinosarcoma

Abstract

We studied 9 lung tumors previously diagnosed as biphasic pulmonary blastoma (PB). This study suggests that beta-catenin gene mutations may play a role in the tumorigenesis of CPB.

Although CPB and BCS have often been grouped together as biphasic PB, they are different entities based on immunohistochemical and molecular analysis of beta-catenin. Immunostaining for beta-catenin is useful for the discrimination.