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Aberrant nuclear/cytoplasmic localization and gene mutation of beta-catenin in classic pulmonary blastoma - beta-catenin immunostaining is useful for distinguishing between classic pulmonary blastoma and a blastomatoid variant of carcinosarcoma

Publikace na Lékařská fakulta v Hradci Králové |
2007

Tento text není v aktuálním jazyce dostupný. Zobrazuje se verze "en".Abstrakt

We studied 9 lung tumors previously diagnosed as biphasic pulmonary blastoma (PB). This study suggests that beta-catenin gene mutations may play a role in the tumorigenesis of CPB.

Although CPB and BCS have often been grouped together as biphasic PB, they are different entities based on immunohistochemical and molecular analysis of beta-catenin. Immunostaining for beta-catenin is useful for the discrimination.