Biotin-rich, optically clear nuclei express estrogen receptor-beta: Tumors with morules may develop under the influence of estrogen and aberrant beta-catenin expression

Abstract

The present study indicates that N/C co-localization of ER-beta and beta-catenin is a feature common to the morules with BROCN that appear in the BROCN-family tumors from various anatomic sites. Whether the estrogen-signaling pathway and the Wnt-signaling pathway have crosstalk, cooperating in the development of the BROCN-family tumors, awaits further study