Impact of clinical and molecular factors on the estimation of colorectal adenomatous polyps recurrence in long-term clinical follow-up patients
2013
Abstract
Colorectal cancer (CRC) development stages (adenomas) are determined by histopathological staging assessing the risk level of cancer development. Colorectal adenomas recurrence increases the requirements of patients follow-up.
The malignant transformation process from normal tissue is accompanied by characteristic changes on genetic and epigenetic disorders level. Main study objective was the long-term (6-11 years) monitoring of patients after endoscopic polypectomy, mainly in relation to presence of recurrent adenomas.
Another goal was to study the genetic profile of the most common somatic DNA mutations and their possible relation to adenoma histopathology characteristics.