Rabbit model for in vivo study of anthracycline-induced heart failure and for the evaluation of protective agents

Abstrakt

Cardiac toxicity associated with chronic administration of anthracycline antibiotics represents a serious complication of their use in anticancer chemotherapy, but can also serve as a useful experimental model of cardiomyopathy and congestive heart failure (induced e.g. by repeated i.v. daunorubicin administration).