The Relation between Skeletal Muscle Blood Flow and Selected Parameters of Metabolism during Cardiac Surgery with Cardiopulmonary Bypass
Abstract
Microdialysis was performed in forty patients undergoing cardiac surgery with a cardiopulmonary bypass (CBP). After an institutional approval, patients were randomized into two groups.
Group 1 (NT, N-20): patients were operated under hypothermic conditions (32 °C). Two microdialysis (MD) probes CMS 60 were inserted into a standard site of musculus deltoideus.
Microdialysis was performed with Ringer`s solution with perfusion flow 0,3 ml/hour. Microdialysis samples were collected: 0) initial phase of operation, 1) beginning of operation to beginning of CPB, 2) CPB 3) end of CPB to the end of operation, 4) 2 hours, 5) 4 hours, 6) 6 hours and 7) 8 hours after surgery.
Microdialysate glucose, urea, lactate and glycerol concetrations were assessed. Interstitial blood was monitored using flow marker gentamicin added in a known concentration in microdialysis fluid.