The binding of aristolochic acid I to the active site of human cytochromes P450 1A1 and 1A2 explains their potential to reductively activate this human carcinogen

Abstract

Reductive activation of human carcinogen (aristolochic acid I) by human cytochromes P450 1A1 and 1A2 was shown. The resulting DNA adducts reproduce the patterns found in renal tissues from humans.

Keywords

• aristolochic acid
• carcinogen
• urothelial cancer
• cytochromes P450 1A1 and 1A2
• reductive activation
• DNA adduct
• computer modeling
• docking