Modulation of adenylyl cyclase activity in young and adult rat brain cortex. Identification of suramin as a direct inhibitor of adenylyl cyclase.
2005
Abstract
Adenylyl cyclase exhibits about 2x lower enzyme activity in cortex from adult than from young rats. This difference is independent of the type of modulators of enzyme activity; suramin may act as a direct inhibitor of enzyme activity of adenylyl cyclase.