A convenient access to thermodynamically nonstabilised spiroketal isomers: the first synthesis of (Z)-7-methyl-1,6-dioxaspiro[4.5]decane

Abstract

Functionalised hydroxy alpha-alkynones were transformed to the corresponding spiroketals by a one-pot cascade consisting of palladium-catalysed hydrogenation of the triple bond, hydroxyl group deprotection and spirocyclisation under mild nonacidic condit

Keywords

• spiroketals
• alpha-alkynones
• diastereoselective synthesis
• nonstabilised isomers
• spiroacetals
• chemistry
• lactones
• route