Dose dependent biological effects of Idarubicin in HL-60 cells: Alterations of the cell-cycle and apoptosis

Abstrakt

TP-53 deficient cells HL-60 die by massive apoptosis after high doses (50-100 nmol/l) of Idarubicin, regardless of the cell-cycle phase. After low dose 10 nmol/l the cells die after cell-cycle arrest in G2 phase.