Rabbit Liver Microsomal System: Study of Interaction with Two Model N-nitrosamines and their Metabolism

Abstract

Different rabbit liver microsomes were incubated with NDMA or NMA and interaction and metabolism were studied. Base on both method the CYP 2E1, the major induced form by ethanol, were validate as the enzyme mainly responsible for activation of both the

Keywords

• rabbit
• microsomes
• N-nitrosamine
• CYP-450
• CYP 2E1