Carbohydrate and non-carbohydrate ligands for the C-type lectin-like receptors of natural killer cells. A review

Abstract

The superfamily of C-type animal lectins is defined by a sequence motif of the carbohydrate recognition domains (CRDs) and comprises seven groups of molecules. The soluble proteins are group I proteoglycans, group III collectins, and group VII containing the isolated CRDs.Type I membrane proteins include group IV selectins and group VI macrophage receptor sand related molecules.

Type II membrane proteins are group II hepatic lectins and group V natural killer cell receptors. The latter group has recently attracted considerable attention of the biomedical community.

Keywords

• Mhc class-i
• low-density-lipoprotein
• histocompatibility complex-molecules
• activating immunoreceptor nkg2d
• delta t-cells
• nk cells
• crystal-structure
• inhibitory receptor
• binding-protein
• recognition domain