DNA adduct formation by the anticancer drug ellipticine and its hydroxy derivatives in human breast adenocarcinoma MCF-7 cells

Abstract

Anticancer drug ellipticine and its hydroxy derivatives form DNA adduct in human breast adenocarcinoma MCF-7 cells

Keywords

• ellipticine
• anticancer drug
• human breast cancer MCF-7 cells
• cytotoxicity
• human cytochrome P450
• activation
• DNA adducts
• 32P-postlabeling
• antineoplastic activity