Abstract
Extension of our implementation of a physiological model of man "HumMod Golem Edition "begins to be possible, for example, to examine in detail the impact of increased production of keto acids on blood gas exchange and the concentration various electrolytes during the simulation period of several months. showed that excess base (base excess) is for complex quantitative models better maintained as dependent variable the total concentrations of the individual electrolyte and acid-base buffers. Just totally quantities of electrolytes and buffers are the actual state variables, which are fully subject The law of conservation of matter.
This new view of counting of acid-base solved the long-term stability of the model, which in previous versions after several weeks of simulation in acid-base disturbances rozchádzala.