Cocyclotrimerization of 6-Alkynylpurines with alfa,omega-Diynes as a Novel Approach to Biologically Active 6-Arylpurines

Abstract

Cocyclotrimerization of 6-alkynylpurines with alfa,omega-diynes afforded a series of variously susbtituted 6-arylpurines. Selected 6-arylpurines were tested for cytostatic activity.

Keywords

• nickel
• cyclotrimerization
• purines
• catalysis