Synthesis of Linear and Branched Regioisomeric Chitooligosaccharides as Potential Mimetics of Natural Killer Cells NKR-P1 and CD69 Lectin Receptor
2004
Abstract
Regioisomer of chitobiose 13 with beta(1-->3) glycosidic bond and branched analog of chitotriose 25 having beta(1-->4) and beta(1-->3) glycosidic bonds, were prepared and tested as potential mimetics of natural oligosaccharide ligands for activating lectin receptors NKR-P1A and CD69 of natural killer (NK) cells. The structural requirements of NKR-P1 lectin receptor on effective mimetics of its natural ligands has been discussed.
A significant binding activity of the branched trisaccharide 25 to the receptor CD69 was observed.