Voltammetric and LC-MS/MS Method for the Determination of Triclosan: A Comparative Study, Validation and Simultaneous Application
Abstract
In this paper, two determination methods of polychlorinated diphenylether triclosan (5-chloro-2-(2,4-dichlorophenoxy) phenol), an antibacterial and antifungal agent, are developed, compared and used in concordance. The first one, differential pulse voltammetry (DPV) on carbon paste electrode (CPE), is simple, fast, portable and inexpensive and therefore suitable for field measurements, large scale monitoring and screening purposes.
The other one, liquid chromatography with MS/MS detection, is much more sophisticated, selective, accurate and sensitive (unfortunately much more expensive as well) and can serve for more reliable determination of triclosan in samples selected as suspicious during the screening measurements. Optimum conditions for both the determinations are described and validation parameters in matrices of drinking and river water are given.