Utilization of cytochromes P450 to explain a new mechanism of action of anticancer drug ellipticine

Abstrakt

Cytochromes P450 activate the anticancer drug ellipticine to the pharmacologically more effictive metabolites binding covalently to DNA in vitro and in vivo.

Klíčová slova

• Stiborová
• Marie
• 221951285 anticancer drug
• ellipticine
• cytochromes P450
• DNA adducts