ANTICANCER DRUG ELLIPTICINE ACTS AS AN INDUCER OF CYTOCHROMES P450 1A1/2 AND POTENTIATES ITS OWN PHARMACOLOGICAL EFFICIENCY

Abstrakt

The expression of hepatic CYP1A1/2 enzymes in rats of both sexes is strongly induced by anticancer drug ellipticine. The induction is transient and strongly dependent on the dose.

Klíčová slova

• STIBOROVÁ MARIE
• 221951285 ELLIPTICINE
• CYTOCHROMES P450 1A1 AND 1A2
• EROD
• MROD
• SUDAN I OXIDATION