Rat microsomes activating the anticancer drug ellipticine to species covalently binding to deoxyguanosine in DNA are a suitable model mimicking ellipticine bioactivation in humans

Abstrakt

Anticancer drug ellipticine is bioactivated by rat enzymatic systems analogously to human Therefeore, rats are a suitable model simulating the fate of ellipticine in humans.

Klíčová slova

• Stiborová
• Marie 221951285 Anticancer drug
• ellipticine
• cytochromes P450
• model organism