Human enzymes involved in the metabolic activation of the environmental contaminant 3-nitrobenzanthrone: evidence for reductive activation by human NADPH:cytochrome P450 reductase

Abstrakt

A strong mutagen and air pollutant 3-nitrobenzanthrone is metaboliyed by human NADPH:cytochrome P450 reductase and human recombinant cytochromes P450 to species binding covalently to DNA

Klíčová slova

• Stiborová
• Marie 221951285 pollutant
• mutagen
• carcinogen
• activation
• 3-nitrobenzanthrone
• NADPH:cytochrome P450 reductase
• cytochromes P450