Mechanism of DNA adduct formation by anticancer drug ellipticine activated by cytochromes P450 in vitro and in vivo

Abstract

The anticancer drug ellipticine is activated by oxidative reaction to species binding to DNA in vitro and in vivo.

Keywords

• Stiborová
• Marie
• 221951285 Anticancer drug
• ellipticine
• pharmacological antivation
• DNA adducts
• cytochromes P450