Synthesis of alpha-amino acids via asymmetric phase transfer-catalyzed alkylation of achiral nickel(II) complexes of glycine-derived Schiff bases

Abstract

Achiral, diamagnetic Ni(II) complexes 1 and 3 have been synthesized from Ni(II) salts and the Schiff bases, generated from glycine and PBP (7) and PBA (11), respectively, in MeONa/MeOH solutions. The requisite carbonyl-derivatizing agents pyridine-2-carb

Keywords

• 2-component molecular-crystal
• enantioselective synthesis
• stereoselective-synthesis
• 2-amino-2'-hydroxy-1,1'-binaphthyl nobin
• practical synthesis
• cinchona alkaloids
• addition-reactions
• michael addition
• hydrogen-cyanide
• highly efficient