Cardiomegaly induced by pressure overload in newborn rats is accompanied by altered expression of the long isoform of Gs alpha protein and deranged signaling of adenylyl cyclase

Abstract

We found out that cardiomegally induced by pressure overload in newborn rats is associated with decreased content of the long form of G(s)alpha protein and impaired function of the catalytic subunit of adenylyl cyclase.

Keywords

• rat myocardium
• pressure overload
• cardiomegaly
• G-proteins
• adenylyl cyclase
• beta-adrenergic responsiveness
• heterotrimeric g-proteins
• cardiac-hypertrophy
• heart-failure