Peroxidase-mediated ellipticine-DNA adduct formation explains the selective efficiency of this anticancer drug against breast cancer and leukemia

Abstract

Durinoxidation of ellipticine by peroxidases, two ellipticine-DNA adducts, which were generated by CYP-mediated reaction, are also formed.

Keywords

• Stiborová
• Marie 221951285 ellipticine
• peroxidases
• CYP
• DNA adduct formation