Human cytochromes P450 1A1/2 and NADPH:cytochrom P450 reductase activate carcinogenic aristolochic acid to form DNA adducts found in patients with Chinese herbs nephropathy

Abstrakt

Carcinogenic aristlochic acid causing the Chinese herbs nephropathy and carcinogenic processes is activated by microsomal cytcorhoems P450 1A1 and 1A2

Klíčová slova

• Stiborová
• Marie
• 221951285 Nephropathy
• tumors
• aristolochic acid
• activation
• cytochromes P450