Metabolic activation of 3-aminobenzanthrone by human liver microsomes and by human recombinant cytochromes P450

Abstract

Reduction metabolite of carcinogenic pollutant 3-nitrobenzanthrone, 3-aminobenzanthrone, is activated by human hepatic microsomes to species binding to DNA.

Keywords

• Stiborová
• Marie
• 221951285 Mutageen
• carcinogen
• 3-aminobenzanthrone
• activation
• oxidation
• cytochromes P450