Abstract
Treatment of gout is currently changed. There is renaissance of colchicine in lower doses in treatment af acute gouty attack .Febuxostat becomes a now possibility of hypouricemic therapy, if allopurinol is not effective or contraindicated.
Combination of hypouricemic therapy with low-dose colchicine is recommended in first 6 months of therapy for increased risk of gouty attacs during mobilisation of tophi. In some situation is useful treament by recombinant uricase or interleukine-1 inhibitors.