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Nicotine partially supresses evoked cortical discharges in adolescent rats exposed to hypoxia

Publication

Abstract

Nicotine is widely used drug of abuse the main psychoactive ungredient of tobacco smoking. This study focused on the possible nebeficial effects of nicotine against the high-altitude hypoxia (9 000 m for one hour) on 35-days-old rats. 15 min prior to hypoxia exposition rats were treated with nicotine.

Next day electrodes have been implanted and the effects of nicotine and hypoxia (or both factors) on duration of afterdischarges (ADs) were tested.