Abstract
Eosinophila is not a disease itself but rather a symptom of different pathologic neoplastic and non- neoplastic disorders. A contemporary proposal on classification of eosinophilic diseases brings a logic to messy labyrinth of different systemic and organic eosinophilic syndormes and makes the issue substantially more clear and understandable.
Eosinophlic syndromes can be either primarily caused by neoplastic proliferation or secondary induced by specific cytokines and growth factors. Blood and tissue eosinophilia can be only isolated finding without any prominent organ manifestation, but it can be also accompanied by serious organ damage and dysfunction.
A careful investigation and differential diagnosis is important for revealing the cause of secondary, reactive, eosinophilia and eventually clonal proliferation in primary eosinophilia. In case we are not able to find the origin of eosinophilic disorder, we used to term it idiopathic eosinophilia.
The exaggerated variant of eosinophilic disorder is termed hypereosinophilic syndrome, which is characterized by increase of eosinophils in peripheral blood above 1,5.109/l and variable tissue and organ manifestation. A treatment of secondary eosinophilic syndromes is mostly symptomatic or nonspecific antiinflammatory (systemic corticosteroids).
Nevertheless new drugs influencing directly proliferation and activation of eosinophils are emerging.