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Pretreatment with Prasugrel in Non-ST-Segment Elevation Acute Coronary Syndromes

Publication at Third Faculty of Medicine, Faculty of Medicine in Hradec Králové |
2013

Abstract

Although P2Y(12) antagonists are effective in patients with non-ST-segment elevation (NSTE) acute coronary syndromes. We evaluated the effect of administering the P2Y(12) antagonist prasugrel at the time of diagnosis versus administering it after the coronary angiography if percutaneous coronary intervention (PCI) was indicated.

We enrolled 4033 patients with NSTE acute coronary syndromes and a positive troponin level who were scheduled to undergo coronary angiography within 2 to 48 hours after randomization. Patients were randomly assigned to receive prasugrel before the angiography (pretreatment group) or placebo (control group).

When PCI was indicated, an additional 30 mg of prasugrel was given in the pretreatment group at the time of PCI and 60 mg of prasugrel was given in the control group. The rate of the primary efficacy end point, a composite of death from cardiovascular causes, myocardial infarction, stroke, urgent revascularization, or glycoprotein IIb/IIIa inhibitor rescue therapy (glycoprotein IIb/IIIa bailout) through day 7, did not differ significantly between the two groups (hazard ratio with pretreatment, confidence interval).

The rate of the key safety end point of all Thrombolysis in Myocardial Infarction major bleeding episodes, whether related or not related to coronary-artery bypass grafting, through day 7 was increased with pretreatment. The rates of TIMI major bleeding and life-threatening bleeding not related to CABG were increased by a factor of 3 and 6, respectively.

Pretreatment did not reduce the rate of the primary outcome among patients undergoing PCI (69%) but increased the rate of TIMI major bleeding at 7 days. All the results were confirmed at 30 days and in prespecified subgroups.

Among patients with NSTE acute coronary syndromes who were scheduled to undergo catheterization, pretreatment with prasugrel did not reduce the rate of major ischemic events up to 30 days but increased the rate of major bleeding complications.