Trends in the Development of COntact Sensitivity to Selected Additives of Pharmaceutical and Cosmetis Products in the Czech Republic
Abstract
In the Czech Republic the trends of development of contact sensitivity to additives in pharmaceutical and cosmetic products in patients with dermatitis are monitored by the section of dermatological allergology of The Czech Society of Dermatology of the Czech Medical Association JEP. Sensitivity to allergens from European standard series e- g. parabens, Quaternium-15, Kathon CG, lanolin alcohol are monitored since 1995.
Sensitivity to bronopol, imidazolidinyl urea, diazolidinyl urea, DMDM-hydantoin, chloroacetamide dibromdicyanobutan/phenoxyethanol a cocamidopropyl betaine is monitored since 2005. In 2011 the frequency of senzition in dermatitis patients (n=2944ú was as follows: 4,1% to Kathon CG, 1,8% to cocamidopropyl betaine, 1,4% to lanolin alcohol, 1,1% to dibromdicyanobutan/phenoxyethanol, 0,9% to parabens, 0,8% to chloroacetamide, 0,7% to Quaternium-15, 0,6% to bronopol and diazolidinyl urea, 9,5% to DMDM-hydantoin and 0,4% to imidazolidinyl urea.
Increased sensitivity to Kathon CG (1,5% in 2001) and decreased sensitivity to lanolin alcohol (3,8% in 2003) was noticed.