Abstract
The study aimed at determining whether liver regeneration after 70% partial hepatectomy influences bone metabolism in healthy adult male Wistar rats. Rats were distribute into 5 group of 8 animals each.
The first group were controls with no abdominal surgery. Animals in second and third groups underwent laparotomy and 70% partial hepatectomy, respectively, and were sacrificed 24 hours after the procedure.
Animal in group four and five underwent laparotomy and 70% partial hepatectomy, respectively, and sacrificed 72 hours after the procedure. ELISA was used to determine the bone formation markers procollagen type I N-terminal propeptide and osteocalcin and the bone resorption marker C-terminal telopeptide of type I collagen.
C-terminal telopeptide of type I collagen significantly increased in the group sacrificed 72 hours after partial hepatectomy. Laparotomy had no effect on marker concentration in any of the groups.
The results suggest increased bone resorption following 70% partial hepatectomy.