Abstract
Catalase (CAT, H2O2: H2O2 - oxidoreductase, EC: 1.11.1.6) is well studied enzyme that plays an important role in protecting cells against the toxic effects of hydrogen peroxide. The main function of catalase is the decomposition of hydrogen peroxide to water and oxygen.
This review summarizes the information available on the function and role of CAT in the pathogenesis of various pathophysiological states. The activity of CAT was investigated in group of patients with metabolic syndrome, with depressive disorder, sepsis, with chronic pancreatitis, with carcinoma of pancreas and patients with acute pancreatitis.
Results of catalase activities in various pathophysiological states are inconsistent. Future investigations are necessary to elucidate the role of CAT in pathogenesis of oxidative-stress related diseases.