Abstract
The presentation is aimed at a change in the neurodevelopmental hypotheses of an aetiology and pathogenesis of schizophrenia, including their recent adaptations - dysconnection hypothesis and synaptic hypothesis. The focus of neurodevelopmental conceptualizations has been shifted from an undefined developmental lesion to the synapsis and its dysfunction.
Stationary findings of synaptic dysfunctions were integrated into the conceptualization of schizophrenia as a consequence of the disintegration in large-scale temporal synchronization of distributed cortical networks, in agreement with neurodevelopmental view of pathogenesis of schizophrenia. The progress in neuroimagining and more accurate findings in this field are the prerequisite for the formulation of an integrated scientific paradigm of etiopatogenesis of schizophrenia.