The issue of pain and pain management permeates all fields of medicine, especially so in the surgical disciplines. For daily practice in pain treatment, it is necessary to know the general principles of how pain originates and spreads and the principles on which therapeutic methods which are currently used to reduce and eliminate pain are based.
In this review, we reiterate the most important new findings about the pathophysiology of pain and the therapeutic methods developed on the basis of those: pharmacological, psychological, physiotherapeutic, surgical and neuromodulatory. We also deal with the mechanisms of orthopaedic pain such as back pain, joint pain, muscle and bone pains, as well as some specific painful conditions that affects multiple organ systems, such as fibromyalgia.