Abstract
Summary of issues : Magnesium is the fourth most common cations in the human body and after the second cation of potassium in the intracellular compartment. Participates as a cofactor for enzymes of metabolic reactions, formation and utilization of energy and is necessary to maintain electrolyte balance.
The body of an adult contains about 0.043 % ( 535-730 mmol ) of magnesium , which is the equivalent of about 22-30 g ( 60% of the bony skeleton , 40 % intracellularly in muscles and soft tissues , 1% ( 7.5-10 mmol ) is contained in the extracellular fluid ). The daily requirement of magnesium is estimated at 10 to 20 mmol, i.e. 200-400 mg.
In relation to the dose then applies that the higher the dose administered , the lower the percentage of rezorbce intestine. The recommended daily dose of 15 mmol (365 mg) is resorbed only about 1 /3 full.
The importance of magnesium in pregnancy : implications manifest lack of magnesium can be: 1 increased risk of miscarriage - premature birth ( cervical incompetence , premature rupture of amniotic fluid ) , 2nd placental insufficiency and fetal hypotrofizace , 3rd Development gestosis the mother , 4th increased risk of asthma and eczema in children. Magnesium sulfate given to pregnant threatened preterm labor ( 23 +0 -30 +0 ) reduces the risk of cerebral palsy in surviving newborns.
Summary : Not recommended for use intravenous magnesium sulfate in the treatment indication preterm birth for more than 5-7 days. This restriction does not apply to the use of oral magnesium.