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Non-alcoholic steatosis and steatohepatitis

Publication at First Faculty of Medicine |
2013

Abstract

Non-alcoholic fatty liver (for whom English is far more appropriate name "non -alcoholic fatty liver disease" - NAFLD) represents a broad spectrum of liver disease ranging from simple steatosis, non-alcoholic steatohepatitis through (NASH) with typical inflammation of the liver parenchyma and deposition of connective tissue to liver cirrhosis with all its complications, including hepatocellular carcinoma. Previously it was assumed that a diagnosis of fatty liver non-alcohol not too frequent and that this disease does not lead to a more severe hepatic impairment. with the growing number of findings that show a clear relationship NAFLD to lifestyle diseases, it seems that NAFLD is the most common cause of abnormal liver function tests and subsequent chronic liver diseases in both developed and developing countries.

Presence of NAFLD is closely associated with the presence of individual components of the metabolic syndrome such as central obesity, impaired glucose tolerance, diabetes mellitus type 2, arterial hypertension, hypertriglyceridemia and NAFLD is thus considered part of, or even the hepatic manifestation of the metabolic syndrome. In this context, it is likely that a significant increase in the prevalence of NAFLD is related to the increasing prevalence of obesity and its accompanying risk factors.