Influence of treatment with sildenafil on lung function and exercise tolerance in cystic fibrosis adults

Abstract

Phosphodiesterase 5 (IPDE5) in the experiment restore chloride transport to the epithelial cells of the respiratory tract in cystic fibrosis (CF) mutation F508del. Patients with CF with severe lung disease are at risk of impaired exercise tolerance.

Treatment with IPDE5 with CF is a promising strategy.

Keywords

• cystic fibrosis
• sildenafil